Aprecap 125mg/80mg Capsule contains Aprepitant. It is an antiemetic drug used to stop nausea and vomiting that come with surgery and chemotherapy.

Brand Name: Aprecap

Composition: Aprepitant

Mechanism of Action:

The body quickly transforms Fosaprepitant into Aprepitant after it is administered. Aprepitant blocks the function of substance P, a neurotransmitter involved in the vomiting reflex, by acting as an antagonist of the neurokinin-1 (NK1) receptor. This successfully prevents nausea and vomiting, both acute and delayed.

Uses:

Prevention of Nausea and Vomiting due to Chemotherapy

Dosage and Administration:

Take one 125 mg capsule of Aprecap orally 1 hour before chemotherapy. The capsules should be taken with or without food.

Side Effects:

• Fatigue
• Dizziness
• Headache
• Diarrhea
• Hiccup
• Constipation

Safety Advise:

Liver  

Caution is advised in patients with hepatic impairment, and dosage adjustments may be necessary. Kindly speak with your healthcare provider.

Kidney  

Caution is advised in patients with renal impairment, and dosage adjustments may be necessary. Kindly speak with your healthcare provider.

Pregnancy  

It should only be used if absolutely necessary because its safety during pregnancy has not been thoroughly demonstrated. Kindly speak with your healthcare provider.

Breast Feeding  

Using Aprecap 125mg Capsule while nursing is most likely dangerous. Kindly speak with your healthcare provider.

Alcohol  

Alcohol consumption while using Aprecap 125mg Capsule is not advised. Kindly speak with your healthcare provider.

Storage:

Store the capsules at room temperature (15°C to 30°C). Keep them in the original packaging, protected from light and moisture.

How to use this Medication?

During the first several days of chemotherapy, aprepitant capsules are given orally, often once daily, beginning one hour prior to treatment. If you have any questions, ask your doctor or pharmacist and make sure you are taking your medication as directed.

There are two strengths available for Aprepitant pills. You can be prescribed both strengths by your physician to take at various times. As instructed by your physician, you should take the appropriate strength at the appropriate time.

Do not break, chew, or crush the capsules; instead, swallow them whole.

References:

1.   Aapro M, Carides A, Rapoport BL, Schmoll HJ, Zhang L, Warr D. Aprepitant and fosaprepitant: a 10-year review of efficacy and safety. The oncologist. 2015 Apr 1;20(4):450-8.

2.    Patel P, Leeder JS, Piquette‐Miller M, Dupuis LL. Aprepitant and fosaprepitant drug interactions: a systematic review. British journal of clinical pharmacology. 2017 Oct;83(10):2148-62.

3.   Dushenkov A, Kalabalik J, Carbone A, Jungsuwadee P. Drug interactions with aprepitant or fosaprepitant: review of literature and implications for clinical practice. Journal of Oncology Pharmacy Practice. 2017 Jun;23(4):296-308.

4.     Xue F, Liu X, Qi X, Zhou J, Liu Y. The clinical research study for fosaprepitant to prevent chemotherapy-induced nausea and vomiting: A review. Advances in Clinical and Experimental Medicine. 2023;32(6):701-6.

Disclaimer:

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Marketer details

Name: Glenmark Pharmaceuticals Ltd

Address: Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai – 400 026.

Country of origin: India