Icikinase 1.5MIU Injection contains Streptokinase, is used to dissolve blood clots for conditions such as deep vein thrombosis, pulmonary embolism, and heart attack. It works by dissolving fibrin clots and reestablishing blood flow in blocked blood arteries.

Brand Name: Icikinase

Composition: Streptokinase

Mechanism of Action:

Streptokinase is a thrombolytic substance. It dissolves blood clots and improves blood flow by changing plasminogen into plasmin, an enzyme that breaks down fibrin clots.

Uses:

·       Heart attack

·       Pulmonary embolism

·       Deep vein thrombosis (DVT)

·       Arterial thrombosis

Dosage and Administration:

Given intravenously in a hospital under close medical monitoring. The patient's condition and the indication determine the dosage and duration.

Uses:

·       Fever

·       Hypotension

·       Nausea

·       Vomiting

·       Injection site reaction

·       Bleeding

·       Allergic reactions

Safety Advise:

Kidney  

Monitor kidney function regularly, as Icikinase can cause nephrotoxicity. Kindly speak with your healthcare provider.

Liver  

Monitor liver function regularly, as Icikinase can cause liver impairement. Kindly speak with your healthcare provider.

Pregnancy  

Icikinase should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

Breast Feeding  

Using Icikinase while nursing is most likely dangerous. Kindly speak with your healthcare provider.

Alcohol  

Icikinase should not be taken with alcohol. Kindly speak with your healthcare provider.

Storage:

Protect from light and store below 25°C.

Reference:

1.     https://www.mayoclinic.org/drugs-supplements/streptokinase-intravenous-route-intracoronary-route/description/drg-20070834

2.     Klöcking HP. Pharmacology of streptokinase. InFibrinolytics and Antifibrinolytics 1978 Sep 1 (pp. 151-177). Berlin, Heidelberg: Springer Berlin Heidelberg.

3.     Tillett WS, Johnson AJ, McCarty WR. The intravenous infusion of the streptococcal fibrinolytic principle (streptokinase) into patients. The Journal of Clinical Investigation. 1955 Feb 1;34(2):169-85.

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