Intajac 5mg Tablet contains Tofacitinib is a medication used primarily for treating certain autoimmune diseases such as Rheumatoid Arthritis, Psoriatic Arthritis, Ulcerative Colitis.

Brand Name: Intajac

Composition: Tofacitinib

Mechanism of action: 

Tofacitinib inhibits Janus kinases (JAK1, JAK2, JAK3), which are key in cytokine signaling for immune cell function. By blocking JAK activity, it reduces the production of inflammatory cytokines, lowering inflammation and immune response. This helps in managing autoimmune diseases like rheumatoid arthritis (RA) and ulcerative colitis.

Uses:

·         Rheumatoid Arthritis

·         Psoriatic Arthritis

·         Ulcerative Colitis

·         Juvenile Idiopathic Arthritis

Side Effects:

·         Headache

·         Diarrhea

·         Dizziness

·         Fever

·         Increased blood cholesterol levels

·         Nausea

·         Vomiting

·         Tuberculosis

·         Shingles

·         Blood clots

·         Neutropenia

·         Risk of malignancy

Safety Advise:

Liver  

Periodic liver function tests should be performed as the drug may increase liver enzymes, indicating liver stress or damage. Kindly speak with your healthcare provider.

Kidney  

Patients with moderate kidney impairment may require dosage adjustments. Tofacitinib is not recommended in cases of severe renal impairment. Kindly speak with your healthcare provider.

Pregnancy  

The use of Tofacitinib during pregnancy is not recommended unless clearly necessary due to a lack of sufficient data on its safety. Kindly speak with your healthcare provider.

Breastfeeding  

It is unknown whether Tofacitinib is excreted in human milk, so caution should be exercised if a mother is breastfeeding. Kindly speak with your healthcare provider.

Alcohol  

Your ability to drive may typically be impacted by Intajac 5mg Tablet. Kindly speak with your healthcare provider.

Storage:

Store at room temperature (20-25°C or 68-77°F). Keep the medication in a dry place, away from excessive moisture and light.

How to use this medication?

Read the Medication Guide provided by your pharmacist before starting to take tofacitinib, and each time you get a refill. If you are using the liquid form, be sure to also read the Instructions for Use. If you have any questions, consult your doctor or pharmacist.

Take this medication by mouth with or without food as prescribed by your doctor, usually once or twice daily.

For the liquid form, carefully measure the dose using a special measuring device or spoon—avoid using a household spoon to ensure accuracy.

To get the full benefit of the medication, take it consistently at the same time(s) every day. Inform your doctor if your condition does not improve or worsens

References:

1.  Dhillon S. Tofacitinib: a review in rheumatoid arthritis. Drugs. 2017 Dec;77:1987-2001.

2.  Cada DJ, Demaris K, Levien TL, Baker DE. Tofacitinib. Hospital pharmacy. 2013 May;48(5):413-24.

3.  Ytterberg SR, Bhatt DL, Mikuls TR, Koch GG, Fleischmann R, Rivas JL, Germino R, Menon S, Sun Y, Wang C, Shapiro AB. Cardiovascular and cancer risk with tofacitinib in rheumatoid arthritis. New England Journal of Medicine. 2022 Jan 27;386(4):316-26.

4.   Sandborn WJ, Ghosh S, Panes J, Vranic I, Su C, Rousell S, Niezychowski W. Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis. New England Journal of Medicine. 2012 Aug 16;367(7):616-24.

Disclaimer:

The main goal of Apothecare Wellness is to make sure that the information it provides to customers is correct, reliable, and reviewed by specialists. This website's contents and information are strictly for informational purposes. They are not meant to be used in place of expert medical advice, diagnosis, or care. Please consult your physician for guidance and ask any questions you may have about any condition or medication. If you read anything on Apothecare Wellness, do not discount or delay obtaining competent medical advice. Our goal is to enhance the doctor-patient relationship, not to take its place.

Marketer details

Name: Intas Pharmaceuticals Ltd

Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.

Country of origin: India

Frequently Asked Questions (FAQs):

1. What is Intajac 5mg Tablet?

Intajac 5mg contains Tofacitinib, a Janus kinase (JAK) inhibitor. It may be prescribed for the management of certain autoimmune conditions. Strict adherence to a rheumatologist's or gastroenterologist's oversight is required.

2. How may Intajac work?

It selectively inhibits JAK enzymes, which may potentially disrupt inflammatory signalling pathways and reduce joint or bowel inflammation.

3. What conditions may it be prescribed for?

It may be considered for moderate-to-severe active rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis, subject to a specialist's evaluation.

4. How is Intajac 5mg administered?

It is taken orally. A common dose may be 5mg twice daily. You must adhere strictly to the schedule prescribed by your physician.

5. Can it be taken with food?

It can generally be taken with or without food, as directed by your healthcare provider.

6. What are the possible side effects?

Patients may potentially experience upper respiratory tract infections, diarrhoea, headache, or nausea. Report any new symptoms to your doctor.

7. Are there serious risks to consider?

Some patients may potentially be at higher risk for serious infections, malignancies, or cardiovascular events. Regular adherence to medical monitoring is crucial.

8. What screening is required before starting?

Screening for TB, Hepatitis, and baseline blood work may be required. You must adhere to all pre-treatment testing guidelines.

9. Can it be used with other medications?

It may potentially be used in combination with methotrexate, but must not be combined with biologic therapies. Adhere strictly to your doctor's medication list.

10. Is it safe during pregnancy?

It is generally not appropriate for pregnant women due to potential risks. Adhere to your doctor's contraceptive advice.

11. Is regular blood monitoring required?

Yes, your doctor will mandate blood tests to monitor liver function, cholesterol, and blood counts. You must attend these scheduled checks.

12. Is Intajac a prescription medicine?

Yes. It is a prescription-only medicine.

Medical Disclaimer:

Intajac 5mg Tablet is a prescription-only medicine and must be used strictly under the supervision and guidance of a qualified healthcare professional. Do not self-medicate, alter the dosage, or discontinue use without consulting your doctor. The information provided here is for educational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Individual results, benefits, and risks may vary. Always consult your physician before starting, changing, or stopping any medication.