Rapacan 1mg Tablet contains Sirolimus, which is an immunosuppressive drug used primarily to prevent organ rejection in transplant patients and to treat certain conditions related to the immune system.

Brand Name: Rapacan

Composition: Sirolimus 1 mg 

Mechanism of Action:

By inhibiting the function of the mammalian target of rapamycin (mTOR), a crucial regulator of cell growth and metabolism, sirolimus prevents T-lymphocytes from activating and proliferating in response to antigenic and cytokine stimulation.

Uses:

• Prevention of organ rejection in kidney transplant recipients, usually as part of a combination immunosuppressive regimen.

Dosage and Administration:

For kidney transplants, a maintenance dose of 2 mg once daily may be administered after an initial loading dose, typically 6 mg, on the day of the transplant. Oral Rapacan tablets can be taken with or without meals. When it comes to meals, consistency is crucial.

Sirolimus dosing is individualized based on therapeutic drug monitoring and trough blood levels. When used concomitantly with cyclosporine, appropriate dosing and administration timing should be considered.

Avoid grapefruit/grapefruit juice, which can raise sirolimus exposure.

 Side Effects:

• Headache
• Edema
• High cholesterol/triglycerides
• High blood pressure
• Nausea
• Fever
• Vomiting
• Joint Pain
• Abdominal pain
• Constipation
• Chills
• Cough
• High Blood Pressure
• Dizziness
• Weight Loss
• Insomnia

Contraindications/Warnings: 

Important warnings include:
Serious infections due to immunosuppression
Increased risk of malignancy, especially lymphoma and skin cancer
Delayed wound healing
High cholesterol/triglycerides
Low blood cell counts
Proteinuria
Interstitial lung disease/pneumonitis
Drug interactions via CYP3A4/P-gp

Safety Advise:

Liver  

Patients with liver illness should use Rapacan with caution. Rapacan dosage adjustments might be required. Kindly speak with your healthcare provider.

Kidney  

Patients with renal illness should use Rapacan with caution. Rapacan dosage adjustments might be required. Kindly speak with your healthcare provider.

Pregnancy  

Animal studies suggest that Sirolimus could be harmful to the fetus, so it may not be safe to use during pregnancy. Before using it, discuss benefits and risks with your healthcare provider.

Breast Feeding  

Using Rapacan while nursing is most likely dangerous. The medication may damage the developing baby if it enters the breastmilk, according to limited human data. Kindly speak with your healthcare provider.

Alcohol  

It is unknown if drinking alcohol while using Rapacan is unsafe. Kindly speak with your healthcare provider.

Storage:

Store at room temperature (20-25°C or 68-77°F) in a tightly closed container, away from light and moisture.

How to use this Medication?

As prescribed, take this medication orally at the same time each day, right after waking up, and with no more than four ounces of plain water. After ingesting the tablets whole, wait at least half an hour before eating, drinking, or taking any other drugs.

With every prescription and refill, the pharmacist will provide you with a unique MedGuide. Every time, make sure to carefully read this information.

 

Discuss the usage of this drug in children with your care team. Extra caution could be required.

References:

1.   Sehgal SN. Sirolimus: its discovery, biological properties, and mechanism of action. InTransplantation proceedings 2003 May 1 (Vol. 35, No. 3, pp. S7-S14).  Elsevier.

2.   Stallone G, Infante B, Grandaliano G, Gesualdo L. Management of side effects of sirolimus therapy. Transplantation. 2009 Apr 27;87(8S):S23-6.

3.   Stenton SB, Partovi N, Ensom MH. Sirolimus: the evidence for clinical pharmacokinetic monitoring. Clinical pharmacokinetics. 2005 Aug;44:769-86.

4.   Mahalati K, Kahan BD. Clinical pharmacokinetics of sirolimus. Clinical pharmacokinetics. 2001 Aug;40:573-85.

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Marketer details

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Country of origin: India