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Tenohep AF 25mg Tablet contains Tenofovir Alafenamide (TAF), which is a prodrug of Tenofovir and is used basically for the treatment of chronic hepatitis B and HIV infection.
Inform your doctor if you have skin problems or liver/kidney disease, and you may need regular blood tests while using this medicine. Avoid alcohol, consult your doctor if pregnant or breastfeeding, and practice safe sex to prevent HIV transmission if you are HIV positive.
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Tenohep AF 25mg Tablet contains Tenofovir Alafenamide (TAF), which is a prodrug of Tenofovir and is used basically for the treatment of chronic hepatitis B and HIV infection.
Brand Name: Tenohep AF
Composition: Tenofovir Alafenamide
Mechanism of Action:
The body transforms tenofovir alafenamide into tenofovir, which subsequently suppresses the reverse transcriptase enzyme. By preventing viral replication, this activity lowers the viral burden and promotes immune system recovery.
Uses:
Chronic Hepatitis B virus infection
HIV Infection
Dosage and Administration:
For chronic hepatitis B, a dosage of 25 mg once daily is typically suggested. The dosage for HIV treatment may change according on the particular combination regimen that is advised.
Side Effects:
Safety Advise:
Liver 
It may be essential to perform routine liver function testing, particularly for individuals with liver disease. Kindly speak with your healthcare provider.
Kidney
It may be essential to perform routine renal function testing, particularly for individuals with renal disease. Kindly speak with your healthcare provider.
Pregnancy
It is important to speak with your healthcare provider before using Tenohep AF 25mg Tablet if you are pregnant or intend to become pregnant.
Breast Feeding
The possible dangers to the newborn are not fully known, considering the fact that Tenohep AF 25mg Tablet is excreted into human breast milk. Kindly speak with your healthcare provider.
Alcohol
It is usually advised to stay away from drinking too much alcohol when using Tenohep AF 25mg Tablet. Kindly speak with your healthcare provider.
Storage:
Store the tablet at room temperature, between 15°C to 30°C (59°F to 86°F). Humidity: Keep the medication in a dry place and protect it from moisture.
How to use this Medication?
Take this medication orally at the same time every day, as directed on the prescription label, along with a glass of water and food. Unless your care team advises you otherwise, take your medication as prescribed; skipping doses increases the risk of developing viral resistance.
Discuss the usage of this drug in children with your care team. Precautions do need to be taken, even though it can be administered to kids as young as 12 for specific conditions.
Get in touch with an emergency department or poison control center right away if you believe you may have taken too much of this medication.
References:
1. De Clercq E. Tenofovir alafenamide (TAF) as the successor of tenofovir disoproxil fumarate (TDF). Biochemical pharmacology. 2016 Nov 1;119:1-7.
2. Wassner C, Bradley N, Lee Y. A review and clinical understanding of tenofovir: tenofovir disoproxil fumarate versus tenofovir alafenamide. Journal of the International Association of Providers of AIDS Care (JIAPAC). 2020 Apr 15;19:2325958220919231.
3. Scott LJ, Chan HL. Tenofovir alafenamide: a review in chronic hepatitis B. Drugs. 2017 Jun;77(9):1017-28.
4. Gibson AK, Shah BM, Nambiar PH, Schafer JJ. Tenofovir alafenamide: a review of its use in the treatment of HIV-1 infection. Annals of Pharmacotherapy. 2016 Nov;50(11):942-52.
Disclaimer:
The main goal of Apothecare is to make sure that the information it provides to customers is correct, reliable, and reviewed by specialists. This website's contents and information are strictly for informational purposes. They are not meant to be used in place of expert medical advice, diagnosis, or care. Please consult your physician for guidance and ask any questions you may have about any condition or medication. If you read anything on Apothecare, do not discount or delay obtaining competent medical advice. Our goal is to enhance the doctor-patient relationship, not to take its place.
Marketer details
Name: Zydus Cadila
Address: Zydus Tower, Satellite Cross Roads, Ahmedabad – 380015 Gujarat, India.
Country of origin: India
Tenohep AF contains Tenofovir alafenamide, an antiviral medication. It may be prescribed for the treatment of chronic hepatitis B virus (HBV) infection. Strict adherence to a hepatologist's oversight is required.
2. How may Tenohep AF work?
It is believed to inhibit the reverse transcriptase enzyme, which may potentially suppress the replication of the hepatitis B virus and reduce liver damage.
3. What conditions may it be prescribed for?
It is considered for adults and adolescents with chronic hepatitis B infection, based on viral load and liver function tests ordered by a doctor.
4. How is it administered?
It is typically taken orally once daily. Adhering to a consistent daily schedule, as instructed by your doctor, is crucial.
5. Can it be taken with food?
Yes, it is generally advised to take it with food. You must adhere to the specific dietary intake advice provided by your healthcare provider.
6. What are the possible side effects?
Patients may potentially experience headache, nausea, fatigue, or abdominal pain. Discuss any ongoing side effects with your physician.
7. Does it cure Hepatitis B?
It is not a cure; it may potentially help suppress the virus. Long-term adherence to the medication is typically required to maintain viral suppression.
8. Are there bone or kidney risks?
While designed to have potentially less impact on bones and kidneys than older formulations, adherence to regular monitoring by your doctor remains essential.
9. Can I stop taking it abruptly?
Stopping the medication without a doctor's approval may potentially lead to a severe, life-threatening flare-up of hepatitis. Adhere strictly to your doctor's withdrawal protocols if stopping.
10. Is it safe during pregnancy?
It may be considered during pregnancy if clinically necessary. You must strictly adhere to an obstetrician's guidance to manage potential risks.
11. Does it prevent transmission?
It does not prevent the potential transmission of HBV to others. Adherence to safe practices is required to protect others.
12. Is it a prescription medicine?
Yes, it is a prescription-only antiviral medication.
Medical Disclaimer:
Tenohep AF 25mg Tablet is a prescription-only medicine and must be used strictly under the supervision and guidance of a qualified healthcare professional. Do not self-medicate, alter the dosage, or discontinue use without consulting your doctor. The information provided here is for educational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Individual results, benefits, and risks may vary. Always consult your physician before starting, changing, or stopping any medication.