Trombonat 25mg Tablet contains Eltrombopag, is used to treat low platelet counts brought on by chronic hepatitis C virus infection or chronic immunological (idiopathic) thrombocytopenic purpura. Additionally, severe aplastic anemia is treated with it. 

Brand Name: Trombonat

Composition: Eltrombopag

Mechanism of Action:

Eltrombopag's mechanism of action is similar to that of thrombopoietin, a natural hormone that stimulates the production of platelets from megakaryocytes in the bone marrow. Eltrombopag increases platelet production by promoting the proliferation and differentiation of megakaryocyte progenitors through the activation of the thrombopoietin receptor.

Uses:

·         Chronic immune thrombocytopenia

·         Thrombocytopenia in Chronic Hepatitis C Patients

·         Aplastic Anemia

Side effects:

·         Nausea

·         Vomiting

·         Fatigue

·         Headache

·         Diarrhea

·         Dizziness

·         Thrombotic events (blood clots)

·         Hepatotoxicity (liver damage)

·         Bone marrow fibrosis

Dosage and Administration:

Trombonat is administered as orally. Depending on the ailment being treated, different amounts are advised; typical dosages range from 25 mg to 75 mg once day, with adjustments made based on response and platelet counts. It should be taken regularly in relation to meals, whether it is taken with or without food.

Safety Advise:

Lungs  

The safety of Trombonat for individuals with lung issues is uncertain. Kindly speak with your healthcare provider.

Liver  

The safety of Trombonat for individuals with liver issues is uncertain. Kindly speak with your healthcare provider.

Kidney  

The safety of Trombonat for individuals with Kidney issues is uncertain. Kindly speak with your healthcare provider.

Pregnancy   

Trombonat should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

Breast Feeding  

Using Trombonat while nursing is most likely dangerous. Kindly speak with your healthcare provider. 

Storage:        

Storage in 30 °C, keep away from children and place away from sun light.

How to use this Medication?

Take this medication orally. Take this medication with a low-calcium meal, on an empty stomach, or at least 30 minutes before or two hours after eating. For two hours before and four hours after taking this medication, stay away from foods high in calcium, antacids, aluminum, calcium, iron, magnesium, selenium, and zinc products. Take your medication on a regular basis. Avoid taking it more frequently than prescribed. Except as directed by your physician, do not discontinue taking.

Contact an emergency department or poison control center right away if you believe you have taken too much of this medication.

References:

1.      Garnock-Jones KP, Keam SJ. Eltrombopag. Drugs. 2009 Mar;69:567-76.

2.    Bussel JB, Cheng G, Saleh MN, Psaila B, Kovaleva L, Meddeb B, Kloczko J, Hassani H, Mayer B, Stone NL, Arning M. Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. New England Journal of Medicine. 2007 Nov 29;357(22):2237-47.

3.      Scheinberg P. Activity of eltrombopag in severe aplastic anemia. Blood Advances. 2018 Nov 13;2(21):3054-62.

4.      Bussel JB, Pinheiro MP. Eltrombopag. Hematopoietic Growth Factors in Oncology. 2010 Oct 18:289-303.

Disclaimer:

The main goal of Apothecare Wellness is to make sure that the information it provides to customers is correct, reliable, and reviewed by specialists. This website's contents and information are strictly for informational purposes. They are not meant to be used in place of expert medical advice, diagnosis, or care. Please consult your physician for guidance and ask any questions you may have about any condition or medication. If you read anything on Apothecare Wellness, do not discount or delay obtaining competent medical advice. Our goal is to enhance the doctor-patient relationship, not to take its place.

Marketer details

Name: Natco Pharma Ltd

Address: Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India

Country of origin: India

Frequently Asked Questions (FAQs):

1. What is Trombonat 25mg Tablet? 

Trombonat 25mg contains Eltrombopag, a thrombopoietin receptor agonist. It may be prescribed for the management of chronic immune thrombocytopenia (ITP). It requires strict adherence to a haematologist’s oversight.

2. How may Trombonat work?

It is believed to stimulate specific receptors on bone marrow stem cells, which may potentially promote the production and maturation of blood platelets.

3. What conditions may it be prescribed for?

It may be considered for chronic ITP or severe aplastic anaemia in certain patients, subject to your doctor's clinical assessment.

4. How is Trombonat 25mg typically taken?

It is generally taken orally once daily. Adhering strictly to a consistent daily timing, as advised by your doctor, is crucial for optimal absorption.

5. Are there strict dietary restrictions?

Yes. Dairy products, calcium-rich foods, and mineral supplements may significantly reduce absorption. You must adhere strictly to your doctor's instructions to separate these from your dose by several hours.

6. What are the possible side effects?

Patients may potentially experience nausea, diarrhoea, headache, elevated liver enzymes, or anaemia. Report any concerning symptoms to your doctor immediately.

7. Are there serious liver risks?

It may potentially cause hepatotoxicity (liver injury). Adhering to your physician's schedule for regular liver function tests is absolutely mandatory.

8. Can it cause blood clots?

As platelet counts rise, there is a potential risk of thrombotic events. Adhere to all scheduled blood tests so your doctor can manage your dosage safely.

9. What is the usual dose?

The starting dose is typically 25–50mg once daily. Dose adjustments must be made exclusively by a qualified healthcare professional.

10. How quickly may it show effects?

Platelet counts may potentially begin to rise within 1 to 2 weeks, though individual response times vary. Adherence to the treatment is key.

11. Can it be used during pregnancy?

It is generally not recommended during pregnancy. You must strictly adhere to an obstetrician's family planning advice.

12. Is Trombonat a prescription medicine?

Yes. It is a prescription-only medicine used strictly under the supervision of a specialist.

Medical Disclaimer:

Trombonat 25mg Tablet is a prescription-only medicine and must be used strictly under the supervision and guidance of a qualified healthcare professional. Do not self-medicate, alter the dosage, or discontinue use without consulting your doctor. The information provided here is for educational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Individual results, benefits, and risks may vary. Always consult your physician before starting, changing, or stopping any medication.