Venclexta 100mg Tablet includes Venetoclax is an oral prescription medicine used to treat certain blood malignancies, such as chronic lymphocytic leukemia, small lymphocytic lymphoma, and, when combined with other medications, acute myeloid leukemia in certain patient populations.

Brand Name: Venclexta

Composition: Venetoclax 100mg 

Mechanism of Action:

Venetoclax is a specific inhibitor of the anti-apoptotic protein BCL-2, which is overexpressed in several malignancies. By inhibiting BCL-2, it restores the natural process of programmed cell death (apoptosis), which results in the demise of cancer cells.

Uses:

·       Chronic lymphocytic leukaemia

·       Acute myeloid leukaemia

Dosage and Administration:

Venclexta is taken orally once per day, with food. To prevent tumor lysis syndrome (TLS), the dosage is progressively increased over several weeks. Include the recommended ramp-up schedule (20 mg → 50 mg → 100 mg → 200 mg → 400 mg over 5 weeks) and TLS prophylaxis measures, including prophylactic hydration, uric-acid-lowering therapy, and blood chemistry monitoring at each dose increase, particularly in patients with high tumor burden.

Side Effects:

•        Low white blood cell counts
•        Nausea​
•        Diarrhea​
•        Anemia​
•     Thrombocytopenia (low platelets)
•        Fatigue​
•        Upper respiratory tract infections​
•        Tumor lysis syndrome

Contraindications/Warnings:

Tumour lysis syndrome risk at initiation - requires TLS prophylaxis/monitoring with dose ramp-up; serious infections and cytopenias - CBC monitoring; strong CYP3A inhibitors/inducers significantly affect levels - dose-adjust or avoid.hypersensitivity to valganciclovir/ganciclovir/aciclovir; ANC <500/mm3 or platelets <25,000/mm3 - avoid starting; myelosuppression is the key boxed warning - CBC monitoring required; animal data show carcinogenic/teratogenic potential - contraception required; renal dose adjustment essential.

Safety Advise:

Lungs  

The safety of Venclexta Tablet for individuals with lung issues is uncertain. Kindly speak with your healthcare provider.

Liver  

The safety of Venclexta Tablet for individuals with liver issues is uncertain. Kindly speak with your healthcare provider.

Kidney  

Tumor lysis syndrome from this drug directly causes acute kidney injury, so renal function/electrolytes must be closely monitored, especially during dose ramp-up.. Kindly speak with your healthcare provider.

Pregnancy  

Venclexta Tablet should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

Breast Feeding  

Using Venclexta Tablet while nursing is most likely dangerous. Kindly speak with your healthcare provider. 

Storage:

Keep at room temperature (15-30 °C). Store in a dry place away from moisture and sunlight.

How to use this Medication?

Take this medication orally with food and a glass of water. Follow the instructions on your prescription label. Don't cut, crush, or chew this medication. Do not combine with grapefruit juice or consume Seville oranges or starfruit. Take your medications at regular times. Do not take it more frequently than prescribed. Stop taking only if your doctor advises you to.

The pharmacist will provide you with a unique MedGuide along with each prescription and refill. Make sure to read this material thoroughly each time.

References:

1. Mihalyova J, Jelinek T, Growkova K, Hrdinka M, Simicek M, Hajek R. Venetoclax: A new wave in hematooncology. Experimental hematology. 2018 May 1;61:10-25.

2. Bose P, Gandhi V, Konopleva M. Pathways and mechanisms of venetoclax resistance. Leukemia & lymphoma. 2017 Sep 2;58(9):2026-39.

3. Pollyea DA, Amaya M, Strati P, Konopleva MY. Venetoclax for AML: changing the treatment paradigm. Blood advances. 2019 Dec 23;3(24):4326-35.

4. Deeks ED. Venetoclax: first global approval. Drugs. 2016 Jun;76:979-87.

Disclaimer:

The main goal of Apothecare Specialities Pvt Ltd is to make sure that the information it provides to customers is correct, reliable, and reviewed by specialists. This website's contents and information are strictly for informational purposes. They are not meant to be used in place of expert medical advice, diagnosis, or care. Please consult your physician for guidance and ask any questions you may have about any condition or medication. If you read anything on Apothecare Specialities Pvt Ltd, do not discount or delay obtaining competent medical advice. Our goal is to enhance the doctor-patient relationship, not to take its place.

Marketer details

Name: Abbvie Therapeutics India Pvt Ltd
Address: Level 6 & 7, Prestige Obelisk, 3, Kasturba Rd, Ambedkar Veedhi, Bengaluru, Karnataka 560001
Country of origin: India